Engineering The Next Generation of Cell & Gene Therapies

Serotiny invents genes encoding therapeutic multi-domain proteins.

What we do

Versioned Genes

tune cell properties

Serotiny invents new therapeutic genes in high-throughput. Iteratively versioning massive libraries of genes enables Serotiny to take numerous shots on a therapeutic goal.
Versioned Genes

Next-Gen Engineering

for next gen therapies

Serotiny bespoke genes encode the therapeutic multi-domain proteins that undergird the mechanisms of action for cell and gene therapies. We tackle biological complexity using tools that scale - software, dna-synthesis, and sequencing.
Next-Gen Engineering

Improving Therapeutic Properties

for complex disease contexts

Serotiny tunes a cell's therapeutic properties for complex contexts. Whether it's cell killing in a hostile tumor microenvironment or successful insertion into the genome, Serotiny engineers cellular attributes for increased therapeutic effect and reduced toxicity.
Improving Therapeutic Properties

Therapeutic Multi Domain Proteins (tMDP)

Curative CAR- and CRISPR-based therapies encode the first tMDPs; there will be more to come. Although tMDPs are proteins, their therapeutic contexts vary greatly from other kinds of therapeutic proteins such as antibodies or biologics.
  • CARs

    CARs

    Chimeric Antigen Receptors

  • CRISPRs

    CRISPRs

    Next-generation Cas-based Editors

  • Others

    Others

    Therapeutic Multi-Domain Proteins

Expressed in the Patient

Expressed in the Patient

tMPDs are delivered as genetic material and will be expressed in the human cell, never to be purified.
Affect Cellular Function

Affect Cellular Function

tMDP variants provide new functionalities to the cell, often uninformed by protein structure or protein-intrinsic properties.
Combinatorial Complexity

Combinatorial Complexity

The arrangement and identity of multiple distinct, large, and functional domains provide the cell with unique properties.
Diverse Contexts

Diverse Contexts

The therapeutic benefits of tMDPs are distinct for each cell type and cellular context.

01

Design

Rational & scaled design of tMDPs pose distinct challenges from designing antibodies and other biologics.

Rational Design

Optimizing each domain, each protein architecture, and each cellular context creates a massive combinatorial challenge. Serotiny's software guides novel designs using patterns we find in our data.
AI-guided rational design

02

Characterize

High-quantity, high-quality data, collected in primary material.

High-Throughput Mammalian Assays

Every experiment evaluates every design in the right context. We conduct our high-throughput assays in mammalian cells for mammalian phenotypes.
high-throughput assays

03

Learn

Each design informs the other.

Computation & Machine Learning

Serotiny designs its experiments for analysis, enabling the use of ML and computation for cell biology.
Machine learning

Our team

Colin & Justin founded Serotiny to revolutionize the way scientists design the genes encoding multi-domain proteins. The curative promise of gene & cell therapies inspired the therapeutic application of Serotiny's technology. The curative promise of gene and cell therapies drives the Serotiny team to deploy their technology to build the next generation of life-saving tMDPs.

Featured Investors

  • ND Capital
  • 8VC

Featured News

Some of our recent partnerships and press releases.
Want to partner? contact us.
Janssen Collaboration
Serotiny Appoints Chad May, CSO
This collaboration will build on Tessera’s innovations in genome engineering technologies and apply Serotiny’s tMDP mining and design expertise to further optimize Tessera's programmable GENE WRITER proteins, capable of making diverse and directed alterations to the genome.Read more...
Tessera Collaboration
collaborationcell therapy
Twist Biopharma will provide Serotiny with custom DNA libraries that encode CARs exploring novel combinations of receptor domains including receptor signaling domains. Serotiny will then engineer and characterize unique CARs on a large scale to screen for receptor designs with improved therapeutic properties that may be applicable to a wide range of solid tumors.Read more...
Twist Collaboration

Contact us

Please reach out to us about partnering opportunities. We're excited to produce first-in-class therapeutic candidates with strategic cell & gene therapy collaborators.
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